货号	规格	价格	上海	北京	珠海	重庆	武汉
V44597-1mg	≥98%	￥890.00 V44597-1mg ￥890.00 3-5天	0 货期：3-5天	-	-	-	-
V44597-5mg	≥98%	￥2580.00 V44597-5mg ￥2580.00 3-5天	0 货期：3-5天	-	-	-	-
V44597-10mg	≥98%	￥4180.00 V44597-10mg ￥4180.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology.

体外研究：

tcY-NH2 TFA (0-500 μM) inhibits AYPGKF-NH2 (10 μM)-induced platelet (obtained from male albino Sprague–Dawley rats) aggregation, with an IC50 value of 95 μM.
tcY-NH2 TFA potently activates aorta relaxation (RA) and gastric (LM) contraction, with IC50 values of 64 μM (RA) and 1 μM (LM).
tcY-NH2 TFA (Tc-YPGKF-NH2, 400 μM, 5 min) prevents endostatin release and platelet aggregation induced by thrombin or by AY-NH2.
tcY-NH2 TFA (5 μM, 15 min) decreases infarct size (IS) by 51%, and increases recovery of ventricular function by 26% in an isolated heart model.

体内研究：

tcY-NH2 TFA (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology.
tcY-NH2 TFA (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model .
tcY-NH2 TFA (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.171 ml	5.856 ml	11.711 ml
5 mM	0.234 ml	1.171 ml	2.342 ml
10 mM	0.117 ml	0.586 ml	1.171 ml
50 mM	0.023 ml	0.117 ml	0.234 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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