货号	规格	价格	上海	北京	珠海	重庆	武汉
V44619-1mg	≥98%	￥2010.00 V44619-1mg ￥2010.00 3-5天	0 货期：3-5天	-	-	-	-
V44619-5mg	≥98%	￥4040.00 V44619-5mg ￥4040.00 3-5天	0 货期：3-5天	-	-	-	-
V44619-10mg	≥98%	￥6470.00 V44619-10mg ￥6470.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

MAO-A/5-HT2AR-IN-1 (compound I14) is a potent MAO-A and 5-HT2AR dual inhibitor, with IC50 values of 0.004 and 0.014 μM, respectively. MAO-A/5-HT2AR-IN-1 is a potential antidepressant agent.

体外研究：

MAO-A/5-HT2AR-IN-1 (compound I14) (0-4 μM, 24 h) exhibits a significant neurocytoprotective effect on the CORT-induced cell depression model.
MAO-A/5-HT2AR-IN-1 is able to occupy the active cavity of 5-HT2AR and MAO-A with multiple hydrogen bonding forces and π–π stacking interaction.
MAO-A/5-HT2AR-IN-1 exhibits low proliferation inhibitory activities against L02 cells (IC50 > 100 μM), SH-SY5Y (IC50 > 10 μM) and PC12 (IC50 > 10 μM), indicating it has a good safety profile.

体内研究：

MAO-A/5-HT2AR-IN-1 (compound I14) (10 and 20 mg/kg) significantly ameliorates the depression-like behavior of mice.
MAO-A/5-HT2AR-IN-1 (0-1 μM, for 7 days) improves zebrafish locomotion and the depression-like behavior.
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参考文献：

1. Sun X, Li N, et al. Development of MAO-A and 5-HT2AR Dual Inhibitors with Improved Antidepressant Activity. J Med Chem. 2022 Oct 13;65(19):13385-13400.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.077 ml	10.383 ml	20.766 ml
5 mM	0.415 ml	2.077 ml	4.153 ml
10 mM	0.208 ml	1.038 ml	2.077 ml
50 mM	0.042 ml	0.208 ml	0.415 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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