货号	规格	价格	上海	北京	珠海	重庆	武汉
V44638-1mg	≥98%	￥1110.00 V44638-1mg ￥1110.00 3-5天	0 货期：3-5天	-	-	-	-
V44638-5mg	≥98%	￥2790.00 V44638-5mg ￥2790.00 3-5天	0 货期：3-5天	-	-	-	-
V44638-10mg	≥98%	￥4470.00 V44638-10mg ￥4470.00 3-5天	0 货期：3-5天	-	-	-	-
V44638-25mg	≥98%	￥8040.00 V44638-25mg ￥8040.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects.

靶点：

human 5-HT1B Receptor:1.7 nM (IC50); human 5-HT1D Receptor:1.3 nM (IC50); 5-HT1B Receptor:0.9 nM (Kd); 5-HT1D Receptor:1.2 nM (Kd)

体外研究：

The intraperitoneal administration of Alniditan ED50=9 μg/kg dose dependly reduces [125I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation[1].

体内研究：

In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation.

参考文献：

1. Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382(2):103-9.
2. Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.664 ml	13.321 ml	26.643 ml
5 mM	0.533 ml	2.664 ml	5.329 ml
10 mM	0.266 ml	1.332 ml	2.664 ml
50 mM	0.053 ml	0.266 ml	0.533 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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