货号	规格	价格	上海	北京	珠海	重庆	武汉
V44653-1mg	≥98%	￥2550.00 V44653-1mg ￥2550.00 3-5天	0 货期：3-5天	-	-	-	-
V44653-5mg	≥98%	￥5880.00 V44653-5mg ￥5880.00 3-5天	0 货期：3-5天	-	-	-	-
V44653-10mg	≥98%	￥9400.00 V44653-10mg ￥9400.00 3-5天	0 货期：3-5天	-	-	-	-
V44653-25mg	≥98%	￥16900.00 V44653-25mg ￥16900.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy.

体外研究：

PROTAC EGFR degrader 4 (compound P3) has antiproliferative activity against cancer cells A431 (EGFR WT), HCC827 (EGFRdel19) and H1975 (EGFRL858R/T790M) with IC50s of 245 ± 30 nM, 0.83 ± 0.30 nM and 203 ± 21 nM, respectively.
PROTAC EGFR degrader 4 (0.3-100 nM; 48 hours) displays excellent activity of inducing EGFRdel19 degradation with a DC50 values of 0.51 nM.
PROTAC EGFR degrader 4 (3 and 100 nM; 48 hours) dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
PROTAC EGFR degrader 4 (10 and 100 nM; 48 hours) induces 31.07% and 44.80% of HCC827 cell line to undergo apoptosis at concentration of 10 and 100 nM, respectively; and arrests both HCC827 and H1975 cell lines at G1 phase.

保存条件：

2-8°C, 避光, 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.005 ml	5.024 ml	10.047 ml
5 mM	0.201 ml	1.005 ml	2.009 ml
10 mM	0.1 ml	0.502 ml	1.005 ml
50 mM	0.02 ml	0.1 ml	0.201 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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