货号	规格	价格	上海	北京	珠海	重庆	武汉
V44679-5mg	≥98%	￥1330.00 V44679-5mg ￥1330.00 3-5天	0 货期：3-5天	-	-	-	-
V44679-10mg	≥98%	￥2210.00 V44679-10mg ￥2210.00 3-5天	0 货期：3-5天	-	-	-	-
V44679-25mg	≥98%	￥4840.00 V44679-25mg ￥4840.00 3-5天	0 货期：3-5天	-	-	-	-
V44679-50mg	≥98%	￥7750.00 V44679-50mg ￥7750.00 3-5天	0 货期：3-5天	-	-	-	-
V44679-100mg	≥98%	￥12400.00 V44679-100mg ￥12400.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases.

靶点：

RORγ:1 μM (IC50)

体内研究：

SR1555 (10 μM; 24 h) inhibits Il17a gene expression by greater than 70%in EL4 cells.
SR1555 (10 μM; 24 h) inhibits IL-17 protein expression, inhibits TH17 cell differentiation and function, and does not induce cell death during TH17 cell differentiation.
SR1555 (10 μM; 24 h) effectively increases the gene expression of Foxp3 while simultaneously suppressing the gene expression of Rorγt.
SR1555 increases the frequency of T regulatory cells as evidenced by the almost 2-fold increase in the expression of Foxp3+ T cells in the splenocyte culture.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.172 ml	10.86 ml	21.72 ml
5 mM	0.434 ml	2.172 ml	4.344 ml
10 mM	0.217 ml	1.086 ml	2.172 ml
50 mM	0.043 ml	0.217 ml	0.434 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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