货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V44853-250mg	≥98%	￥200.00 V44853-250mg ￥200.00 3-5天	0 货期：3-5天	-	-	-	-
V44853-1g	≥98%	￥490.00 V44853-1g ￥490.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

靶点：

IDO-1:3 μM (IC50, HEK 293-hIDO-1); IDO-1:157 μM (IC50, rhIDO-1); WNV NS2B-NS3:96 μM (IC50)

体外研究：

Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells[1].
Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides -induced fulminant hepatic failure in mice[2].
Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice[4].
Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice[5].

体内研究：

Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively.
Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.
Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.707 ml	13.535 ml	27.07 ml
5 mM	0.541 ml	2.707 ml	5.414 ml
10 mM	0.271 ml	1.354 ml	2.707 ml
50 mM	0.054 ml	0.271 ml	0.541 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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