货号	规格	价格	上海	北京	珠海	重庆	武汉
V44894-1mg	≥98%	￥1640.00 V44894-1mg ￥1640.00 3-5天	0 货期：3-5天	-	-	-	-
V44894-5mg	≥98%	￥3800.00 V44894-5mg ￥3800.00 3-5天	0 货期：3-5天	-	-	-	-
V44894-10mg	≥98%	￥6080.00 V44894-10mg ￥6080.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin.

体外研究：

cPrPMEDAP shows antiproliferative activity in SiHa cells with an EC50 of 290 nM (SiHa cells: HPV-transformed cervical carcinoma cell lines).
PMEG forms an active phosphorylated metabolite, PMEG diphosphate (PMEG-DP), in cells, which inhibits the growth of various transformed cell lines due to potent inhibition of the nuclear DNA polymerases α, δ and ?, resulting in inhibition of DNA synthesis and/or DNA repair. In animal models, PMEG has antiproliferative effects; the utility of PMEG as an antiproliferative agent is limited by its poor cellular permeability and toxicity. cPrPMEDAP has similar antiproliferative effects in vitro and reduced toxicity in vivo but, like PMEG, is negatively charged at physiologic pH and has poor permeability into the skin.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.046 ml	15.231 ml	30.463 ml
5 mM	0.609 ml	3.046 ml	6.093 ml
10 mM	0.305 ml	1.523 ml	3.046 ml
50 mM	0.061 ml	0.305 ml	0.609 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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