| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V45011-1mg |
≥98% | ￥670.00 |
货期：3-5天 | - | - | - | - |
|
V45011-5mg |
≥98% | ￥1490.00 |
货期：3-5天 | - | - | - | - |
|
V45011-10mg |
≥98% | ￥2490.00 |
货期：3-5天 | - | - | - | - |
|
V45011-25mg |
≥98% | ￥5490.00 |
货期：3-5天 | - | - | - | - |
|
V45011-50mg |
≥98% | ￥8770.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | FPR2 agonist 2 is a potent and permeates the blood?brain barrier FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity. | ||||||||||||||||||||
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| 体外研究： | FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood?brain barrier and to accumulate in the brain. | ||||||||||||||||||||
| 体内研究： | FPR2 agonist 2 (compound (S)-11l) (1-100 μM; 48 h) exhibits low cytotoxicity with an EC50 value of 20.8 μM in N9 cells. FPR2 agonist 2 (FPR1/FPR2 HL60 cells) shows agonist activity with EC50s of 0.13 μM, 1.1 μM (IC50s of 0.085 μM, Not determined) for FPR2 and FPR1, respectively. FPR2 agonist 2 (0.1 μM) effectively blocks LPS-induced cell death and NO production and effectively suppresses the effect of LPS stimulation. FPR2 agonist 2 (0.1 μM) counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity. |
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| 参考文献： | 1. Mastromarino M, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem. 2022; 65(6):5004-5028. |
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| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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