货号	规格	价格	上海	北京	珠海	重庆	武汉
V45015-1mg	≥98%	￥1630.00 V45015-1mg ￥1630.00 3-5天	0 货期：3-5天	-	-	-	-
V45015-5mg	≥98%	￥3600.00 V45015-5mg ￥3600.00 3-5天	0 货期：3-5天	-	-	-	-
V45015-10mg	≥98%	￥5780.00 V45015-10mg ￥5780.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SZM679 is a potent, orally active and selective RIPK1 inhibitor with Kd values of 8.6 nM and >5000 nM for RIPK1 and RIPK3, respectively. SZM679 reverses the tumor necrosis factor-induced systemic inflammatory response. SZM679 decreases the Tau hyperphosphorylation, neuroinflammation, and the RIPK1 phosphorylation level in the hippocampus and cortex. SZM679 can be used in research of Alzheimer's disease (AD).

靶点：

RIPK1:8.6 nM (Kd); RIPK3:>5000 nM (Kd)

体外研究：

SZM679 (10-40 mg/kg; i.p.; male C57BL/6 J mice with TNF-induced SIRS models) protects against necroptosis-specific TNF-induced systemic inflammatory response syndrome (SIRS) in vivo.
SZM679 (1 mg/kg; administered intragastrically; once daily for 7 days) improves cognitive function in STZ-induced AD mice.
SZM679 (1 mg/kg; administered intragastrically; once daily for 7 days) rescues brain structure damage with no obvious toxicity and decreases AD biomarkers and decreases the expression levels of inflammatory cytokines and inhibits RIPK1 phosphorylation in the brain tissues of AD mice.

体内研究：

SZM679 (0-10 μM; 24 h; necrotic L929 and HT-29 cells) has an anti-necrosis activity by Inhibiting the RIPK1 pathway with an EC50 value of 2 nM. SZM679 also protects against TNF-α, cycloheximide, and z-VAD-fmk (TCZ)-induced necroptosis. SZM679 protects against necroptosis induced by TZ in a dose dependent manner.
SZM679 (1 μM; 6 h; necrotic HT-29 cells) selectively inhibits the expression of RIPK1 but not RIPK3 or MLKL. SZM679 blocks necrosome formation by inhibiting TSZ-induced phosphorylation of RIPK1.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.691 ml	8.453 ml	16.906 ml
5 mM	0.338 ml	1.691 ml	3.381 ml
10 mM	0.169 ml	0.845 ml	1.691 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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