货号	规格	价格	上海	北京	珠海	重庆	武汉
V45050-1mg	≥98%	￥1940.00 V45050-1mg ￥1940.00 3-5天	0 货期：3-5天	-	-	-	-
V45050-5mg	≥98%	￥4500.00 V45050-5mg ￥4500.00 3-5天	0 货期：3-5天	-	-	-	-
V45050-10mg	≥98%	￥7180.00 V45050-10mg ￥7180.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity.

靶点：

S1PR2:119 nM (EC50); S1PR1:1690 nM (EC50); S1PR3:1950 nM (EC50); S1PR4:>10 μM (EC50); S1PR5:>10 μM (IC50)

体外研究：

CYM-5478 activates S1P2 with an EC50 of 119 nM, has less than 25% efficacy and shows 10-fold lower potency against the other S1P receptor subtypes (EC50 of 1690 nM, 1950 nM, >10 μM, >10 μM for S1P1, S1P3, S1P4, S1P5, respectively).
CYM-5478 (1, 10, 100, 1000, 10000 nM) induces a statistically significant increase in the viability of C6 cells in a dose dependent manner at concentrations above 100 nM under nutrient-deprivation stress produced by serum-starvation. This effect was absent in the presence of 10% fetal bovine serum.
CYM-5478 (10 μM) causes a statistically significant, 3-fold increase in the EC50 of Cisplatin-mediated reduction in the viability of C6 glioma cells. CYM-5478 also attenuated Cisplatin-induced caspase 3/7 activity.
CYM-5478 (10 μM) causes significantly attenuated the increase of ROS in C6 cells exposed to Cisplatin (20 μM; for 24 hours).
CYM-5478 (20 μM) protects neural cells but not breast cancer cells against Cisplatin toxicity (C6 glioma cells: EC50=4.54 μM; GT1-7: EC50=17 μM; SK-N-BE2: EC50=7.44 μM; CLU188: EC50=5.54 μM).

体内研究：

CYM-5478 (1 mg/kg/day; ip) protects against Cisplatin-mediated (3 mg/kg; i.p.; once a week for 3 week) ototoxicity in rats.
CYM-5478 (20 μM) treatment results in near-complete protection from cisplatin-mediated loss of neuromast viability. CYM-5478 pr웿Ůñ샮㡽䇘睜⪰ޏࠃ

参考文献：

1. Deron R Herr, et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Sci Rep. 2016 Apr 15;6:24541.
2. Wei Wang, et al. Sphingosine 1-Phosphate Re웿Ůñ샮㡽䇘睜⪰ޏࠃ䇩睜

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.575 ml	12.874 ml	25.748 ml
5 mM	0.515 ml	2.575 ml	5.15 ml
10 mM	0.257 ml	1.287 ml	2.575 ml
50 mM	0.051 ml	0.257 ml	0.515 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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