货号	规格	价格	上海	北京	珠海	重庆	武汉
V45118-5mg买3赠1	99.16%	￥630.00 V45118-5mg ￥630.00 现货（买3赠1）	5 5	-	-	-	-
V45118-10mg买3赠1	99.16%	￥1080.00 V45118-10mg ￥1080.00 现货（买3赠1）	5 5	-	-	-	-
V45118-25mg买3赠1	99.16%	￥2030.00 V45118-25mg ￥2030.00 现货（买3赠1）	5 5	-	-	-	-
V45118-50mg买3赠1	99.16%	￥3600.00 ￥3240.00 V45118-50mg ￥3240.00 现货（买3赠1）	4 4	-	-	-	-
V45118-100mg促销	99.16%	￥5500.00 ￥4950.00 V45118-100mg ￥4950.00 现货	3 3	-	-	-	-
V45118-200mg促销	≥98%	￥8770.00 ￥7890.00 V45118-200mg ￥7890.00 3-5天	0 货期：3-5天	-	-	-	-
V45118-300mg促销	≥98%	￥12000.00 ￥10800.00 V45118-300mg ￥10800.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively. Alpelisib hydrochloride (BYL-719 hydrochloride) shows antineoplastic activity.

体外研究：

Alpelisib (BYL-719) potently inhibits the 2 most common PIK3CA somatic mutations (H1047R, E545K; IC50s~4 nM). Alpelisib potently inhibits Akt phosphorylation in cells transformed with PI3Kα (IC50=74±15 nM) and shows significant reduced inhibitory activity in PI3Kβ or PI3Kδ isoforms transformed cells (≥15-fold compared with PI3Kα).
Alpelisib (BYL-719, 0-50 μM; 72 hours) inhibits the cell growth of osteosarcoma cell lines MG63, HOS, POS-1 and MOS-J in a dose-dependent manner.
Alpelisib (BYL-719) significantly alters the distribution of cell cycle phases. Alpelisib (BYL-719, 25 μM; 18 hours) induces a cell cycle arrest in the G0/G1 phase of human and murine osteosarcoma cell lines.

体内研究：

Alpelisib (BYL-719) (12.5 mg/kg and 50 mg/kg for C57Bl/6J mice; 50 mg/kg for female Rj:NMRI-nude mice; oral administration; daily) significantly reduces tumor volumes and deposition of ectopic bone matrix.
Alpelisib has moderate terminal elimination half-life (t1/2=2.9±0.2 h) for rat (1 mg/kg, iv).

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.092 ml	10.462 ml	20.924 ml
5 mM	0.418 ml	2.092 ml	4.185 ml
10 mM	0.209 ml	1.046 ml	2.092 ml
50 mM	0.042 ml	0.209 ml	0.418 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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