| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V45447-5mg |
≥98% | ￥900.00 |
货期：3-5天 | - | - | - | - |
|
V45447-10mg |
≥98% | ￥1500.00 |
货期：3-5天 | - | - | - | - |
|
V45447-25mg |
≥98% | ￥3000.00 |
货期：3-5天 | - | - | - | - |
|
V45447-50mg |
≥98% | ￥4900.00 |
货期：3-5天 | - | - | - | - |
|
V45447-100mg |
≥98% | ￥7830.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | SOS1. | ||||||||||||||||||||
| 体外研究： | The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with NSC-70220 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of NSC-70220 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of NSC-70220 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of NSC-70220 overnight resulted in lower expression levels of P-ERK. | ||||||||||||||||||||
| 参考文献： | 1. ARYL SULFONOHYDRAZIDES. WO 2016077793A1. | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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