货号	规格	价格	上海	北京	珠海	重庆	武汉
V45489-1mg	≥98%	￥2490.00 V45489-1mg ￥2490.00 3-5天	0 货期：3-5天	-	-	-	-
V45489-5mg	≥98%	￥5490.00 V45489-5mg ￥5490.00 3-5天	0 货期：3-5天	-	-	-	-
V45489-10mg	≥98%	￥8770.00 V45489-10mg ￥8770.00 3-5天	0 货期：3-5天	-	-	-	-
V45489-25mg	≥98%	￥15700.00 V45489-25mg ￥15700.00 3-5天	0 货期：3-5天	-	-	-	-

大包装询价收藏产品

加入购物车

到货通知，提交手机号入库后将短信通知。

产品描述：

Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.

体外研究：

Manzamine A (5-50 µM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA.
Manzamine A (10 µM) hydrochloride inhibits yeast S. cerevisiae growth by 30%.
Manzamine A hydrochloride displays a few enlarged vacuoles in yeast.
Manzamine A (2.5-10 µM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells.
Manzamine A (1 µM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells.
Manzamine A hydrochloride shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone).

体内研究：

Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice.
Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days.

保存条件：

2-8°C, 干燥, 避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.709 ml	8.544 ml	17.087 ml
5 mM	0.342 ml	1.709 ml	3.417 ml
10 mM	0.171 ml	0.854 ml	1.709 ml
50 mM	0.034 ml	0.171 ml	0.342 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置