货号	规格	价格	上海	北京	珠海	重庆	武汉
V45520-1mg	≥98%	￥1570.00 V45520-1mg ￥1570.00 3-5天	0 货期：3-5天	-	-	-	-
V45520-5mg	≥98%	￥3480.00 V45520-5mg ￥3480.00 3-5天	0 货期：3-5天	-	-	-	-
V45520-10mg	≥98%	￥4930.00 V45520-10mg ￥4930.00 3-5天	0 货期：3-5天	-	-	-	-
V45520-25mg	≥98%	￥7900.00 V45520-25mg ￥7900.00 3-5天	0 货期：3-5天	-	-	-	-
V45520-50mg	≥98%	￥12600.00 V45520-50mg ￥12600.00 3-5天	0 货期：3-5天	-	-	-	-
V45520-100mg	≥98%	￥16600.00 V45520-100mg ￥16600.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究：

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

体内研究：

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.

参考文献：

1. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.539 ml	12.696 ml	25.392 ml
5 mM	0.508 ml	2.539 ml	5.078 ml
10 mM	0.254 ml	1.27 ml	2.539 ml
50 mM	0.051 ml	0.254 ml	0.508 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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