货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V45545-500μg	≥98%	￥4250.00 V45545-500μg ￥4250.00 3-5天	0 货期：3-5天	-	-	-	-
V45545-1mg	≥98%	￥7630.00 V45545-1mg ￥7630.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Anserine-d4 is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

参考文献：

1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
2. Boldyrev AA, et al. The histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance. Adv Enzyme Regul. 1990;30:175-94.
3. Jun Kaneko, et al. Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer's-model mice. Sci Rep. 2017 Oct 3;7(1):12571.

保存条件：

-20°C, 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.094 ml	20.468 ml	40.937 ml
5 mM	0.819 ml	4.094 ml	8.187 ml
10 mM	0.409 ml	2.047 ml	4.094 ml
50 mM	0.082 ml	0.409 ml	0.819 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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