货号	规格	价格	上海	北京	珠海	重庆	武汉
V45553-5mg	≥98%	￥1460.00 V45553-5mg ￥1460.00 3-5天	0 货期：3-5天	-	-	-	-
V45553-10mg	≥98%	￥2350.00 V45553-10mg ￥2350.00 3-5天	0 货期：3-5天	-	-	-	-
V45553-25mg	≥98%	￥4720.00 V45553-25mg ￥4720.00 3-5天	0 货期：3-5天	-	-	-	-
V45553-50mg	≥98%	￥7570.00 V45553-50mg ￥7570.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

NADH-IN-1 has NADH:ubiquinone oxidoreductase inhibitory activity with an IC50 value of 27 μM. NADH-IN-1 can effectively stimulate glucose uptake in vitro. NADH-IN-1 is readily metabolised by the liver. NADH-IN-1 can be used for researching diabetes.

体外研究：

NADH-IN-1 (1 μM) exhibits a short half-life and fast intrinsic clearance indicating that it is readily metabolised by the liver in vivo; shows no adverse effects on primary rat hepatocytes, and does not inhibit the hERG channel[1].
NADH-IN-1 (10 mg/kg; IV or PO; single dosage) produces no observable toxic effects at 10 mg/kg by IV or PO; exhibits a short half-life and high plasma clearance; exhibits high mouse and human serum protein binding, as well as moderate bioavailability[1].

体内研究：

NADH-IN-1 (1 μM) exhibits a short half-life and fast intrinsic clearance indicating that it is readily metabolised by the liver in vivo; shows no adverse effects on primary rat hepatocytes, and does not inhibit the hERG channel.
NADH-IN-1 (10 mg/kg; IV or PO; single dosage) produces no observable toxic effects at 10 mg/kg by IV or PO; exhibits a short half-life and high plasma clearance; exhibits high mouse and human serum protein binding, as well as moderate bioavailability.

参考文献：

1. Devine R, et al. Design, synthesis, and biological evaluation of aryl piperazines with potential as antidiabetic agents via the stimulation of glucose uptake and inhibition of NADH:ubiquinone oxidoreductase. Eur J Med Chem. 2020;202:112416.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.615 ml	13.074 ml	26.148 ml
5 mM	0.523 ml	2.615 ml	5.23 ml
10 mM	0.261 ml	1.307 ml	2.615 ml
50 mM	0.052 ml	0.261 ml	0.523 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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