| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V45556-1mg |
≥98% | ￥2340.00 |
货期：3-5天 | - | - | - | - |
|
V45556-5mg |
≥98% | ￥5990.00 |
货期：3-5天 | - | - | - | - |
|
V45556-25mg |
≥98% | ￥8910.00 |
货期：3-5天 | - | - | - | - |
|
V45556-50mg |
≥98% | ￥17200.00 |
货期：3-5天 | - | - | - | - |
|
V45556-100mg |
≥98% | ￥27600.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2) PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease. | ||||||||||||||||||||
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| 体内研究： | MS159 (0.5-10 μM, 48 h) can induce the degradation of NSD2 protein in a time- and dose-dependent manner while the induced NSD2 degradation is reversible in 293FT cells. MS159 (2.5 μM, 72 h) can effectively degrade NSD2 as well as IKZF1 and IKZF3 in multiple myeloma cell lines KMS11 and H929 while the degradation of IKZF1/3 is mediated through a ubiquitin-proteasome system (UPS-) and cereblon (CRBN-) dependent mechanism. MS159 (2.5 μM, 8 days) can effectively inhibit the growth of KMS11 and H929 multiple myeloma cells through induced NSD2 degradation. |
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| 保存条件： | 2-8°C, 避光, 干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京