货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V45566-1mg	≥98%	￥1840.00 V45566-1mg ￥1840.00 3-5天	0 货期：3-5天	-	-	-	-
V45566-5mg	≥98%	￥4950.00 V45566-5mg ￥4950.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V45566-1mg

≥98%

￥1840.00

货期：3-5天

V45566-5mg

≥98%

￥4950.00

货期：3-5天

产品描述：

Ropivacaine-d7 is deuterium labeled Ropivacaine. Ropivacain is a potent?sodium channel?blocker. Ropivacain blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of neuropathic pain?management.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

参考文献：

1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
2. Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717.
3. Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321.
4. Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth
5. Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.553 ml	17.766 ml	35.532 ml
5 mM	0.711 ml	3.553 ml	7.106 ml
10 mM	0.355 ml	1.777 ml	3.553 ml
50 mM	0.071 ml	0.355 ml	0.711 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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