货号	规格	价格	上海	北京	珠海	重庆	武汉
V45681-1mg	≥98%	￥810.00 V45681-1mg ￥810.00 3-5天	0 货期：3-5天	-	-	-	-
V45681-5mg	≥98%	￥1980.00 V45681-5mg ￥1980.00 3-5天	0 货期：3-5天	-	-	-	-
V45681-10mg	≥98%	￥3100.00 V45681-10mg ￥3100.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation-.

体外研究：

CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation.
CD31 is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells.
Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis.
CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB, with the membrane proximal Ig6 domain.
CD31 also serves as a therapeutic target in atherosclerosis.
CD31 (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner.

参考文献：

1. Caligiuri G. Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019 Jul 1. 115(9):1425-1434.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.384 ml	1.922 ml	3.845 ml
5 mM	0.077 ml	0.384 ml	0.769 ml
10 mM	0.038 ml	0.192 ml	0.384 ml
50 mM	0.008 ml	0.038 ml	0.077 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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