货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V45746-1mg	≥98%	￥3190.00 V45746-1mg ￥3190.00 3-5天	0 货期：3-5天	-	-	-	-
V45746-5mg	≥98%	￥8570.00 V45746-5mg ￥8570.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

(+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

靶点：

Serine hydroxymethyltransferase (SHMT)

体外研究：

(+)SHIN2 (0-10 μM; 24 h) blocks proliferation of HCT116 Ras-driven colon cancer cells, in a stereoselective manner with an IC50 value of 300 nM.
(+)SHIN2 (0-100 μM; 48 h) achieves a nearly complete blockade of SHMT activity as evidenced by the decrease in M+1 and M+2 serine, M+2 glycine, and the incorporation of serine-derived glycine and 1C units into ATP, GTP, and dTTP (M+1-M+4 ATP and GTP and M+1 dTTP), and inhibits human T-ALL cell line Molt4 growth with a IC50 value of 89 nM.
(+)SHIN2 (2 μM; 24 h) arrests cell cycle at S phase.

体内研究：

(+)SHIN2 (200 mg/kg; i.p.; single dose) shows therapeutic activity in mouse primary T-ALL in vivo.

参考文献：

1. García-Cañaveras JC, et al. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021 Feb;35(2):377-388.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.46 ml	12.301 ml	24.601 ml
5 mM	0.492 ml	2.46 ml	4.92 ml
10 mM	0.246 ml	1.23 ml	2.46 ml
50 mM	0.049 ml	0.246 ml	0.492 ml

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部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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