货号	规格	价格	上海	北京	珠海	重庆	武汉
V45783-5mg	≥98%	￥970.00 V45783-5mg ￥970.00 3-5天	0 货期：3-5天	-	-	-	-
V45783-10mg	≥98%	￥1390.00 V45783-10mg ￥1390.00 3-5天	0 货期：3-5天	-	-	-	-
V45783-25mg	≥98%	￥2290.00 V45783-25mg ￥2290.00 3-5天	0 货期：3-5天	-	-	-	-
V45783-50mg	≥98%	￥3970.00 V45783-50mg ￥3970.00 3-5天	0 货期：3-5天	-	-	-	-
V45783-100mg	≥98%	￥6350.00 V45783-100mg ￥6350.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo.

靶点：

ERα;ERβ

体外研究：

MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI).

体内研究：

MPP (1, 5, 10, 25, 50 and 100 μM; 24 h) decreases cell viability with an IC50 value of 20.01 μM in RL95-2 cells.
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells.
MPP dihydrochloride (20 μM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα.

参考文献：

1. Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672.
2. Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.
3. Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73(8):1034-44.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.976 ml	9.881 ml	19.761 ml
5 mM	0.395 ml	1.976 ml	3.952 ml
10 mM	0.198 ml	0.988 ml	1.976 ml
50 mM	0.04 ml	0.198 ml	0.395 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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