| 产品描述: | AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway. |
| 体内研究: |
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium accumulation disrupts the mitochondrial tubular network in H9c2 cells through Treatment with 100 µM Zidovudine (AZT) for 48h. AZT triphosphate tetraammonium accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate tetraammonium causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts. |
| 保存条件: |
-20°C, 避光,干燥 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.738 ml |
8.691 ml |
17.382 ml |
| 5 mM |
0.348 ml |
1.738 ml |
3.476 ml |
| 10 mM |
0.174 ml |
0.869 ml |
1.738 ml |
| 50 mM |
0.035 ml |
0.174 ml |
0.348 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |