货号	规格	价格	上海	北京	珠海	重庆	武汉
V45882-1mg	≥98%	￥2030.00 V45882-1mg ￥2030.00 3-5天	0 货期：3-5天	-	-	-	-
V45882-5mg	≥98%	￥4490.00 V45882-5mg ￥4490.00 3-5天	0 货期：3-5天	-	-	-	-
V45882-10mg	≥98%	￥7180.00 V45882-10mg ￥7180.00 3-5天	0 货期：3-5天	-	-	-	-

大包装询价收藏产品

加入购物车

到货通知，提交手机号入库后将短信通知。

产品描述：

P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease.

靶点：

AChE

体外研究：

P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].
P11149 exhibits greater s.c. bioavailability than p.o. [1].
Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats[1].
P11149 exhibits T1/2(el) of 2.4 h and Cmax of 585 ng/mL in rat plasma[1].

体内研究：

P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG.
P11149 exhibits greater s.c. bioavailability than p.o. .
Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats.
P11149 exhibits T1/2(el) of 2.4 h and Cmax of 585 ng/mL in rat plasma.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.119 ml	10.593 ml	21.186 ml
5 mM	0.424 ml	2.119 ml	4.237 ml
10 mM	0.212 ml	1.059 ml	2.119 ml
50 mM	0.042 ml	0.212 ml	0.424 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置