货号	规格	价格	上海	北京	珠海	重庆	武汉
V46062-5mg	≥98%	￥680.00 V46062-5mg ￥680.00 3-5天	0 货期：3-5天	-	-	-	-
V46062-10mg	≥98%	￥1120.00 V46062-10mg ￥1120.00 3-5天	0 货期：3-5天	-	-	-	-
V46062-25mg	≥98%	￥2250.00 V46062-25mg ￥2250.00 3-5天	0 货期：3-5天	-	-	-	-
V46062-100mg	≥98%	￥3600.00 V46062-100mg ￥3600.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Trimethoprim hydrochloride is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim hydrochloride is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim hydrochloride has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim hydrochloride can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.

体外研究：

Trimethoprim (10 mg/kg; i.v.; once every 12 h; 3 d) shows antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis in infected mice[2].
Trimethoprim can be connected with the thiomaltose (TM-TMP) and shows stability with a half-life of about 1 hour in complete serum, and has an MIC value around 1 μM against E. coli[2].
Trimethoprim (10 mg/mL; 0.5 mL; inject with Trimethoprim-Zn combined suspension) decreases the virus titer and increases the survival rate of chicken embryo[4].

体内研究：

Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).
Trimethoprim (3 μg/mL; 1 h) induces protein aggregation and main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim sulfate presence leads to protein misfolding.
Trimethoprim (1.5-3 μg/mL; 1 h) causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps in E. coli cells exposed to folate and heat stress.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.06 ml	15.301 ml	30.602 ml
5 mM	0.612 ml	3.06 ml	6.12 ml
10 mM	0.306 ml	1.53 ml	3.06 ml
50 mM	0.061 ml	0.306 ml	0.612 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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