货号	规格	价格	上海	北京	珠海	重庆	武汉
V46151-1mg	≥98%	￥1550.00 V46151-1mg ￥1550.00 现货	10 10	-	-	-	-
V46151-5mg	≥98%	￥3910.00 V46151-5mg ￥3910.00 现货	9 9	-	-	-	-
V46151-10mg	≥98%	￥5590.00 V46151-10mg ￥5590.00 现货	5 5	-	-	-	-
V46151-25mg	≥98%	￥8610.00 V46151-25mg ￥8610.00 现货	2 2	-	-	-	-

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产品描述：

Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D).

体外研究：

Cotadutide stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively).
Cotadutide (100 pM-1 μM) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β-cell line and increases glucose output in rat hepatocytes.
Cotadutide (100 nM, 2 h) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes.

体内研究：

Cotadutide (10 nmol/kg, s.c., once) suppresses food intake in DIO mice relative to vehicle-treated controls.
Cotadutide (10 or 30 nmol/kg, s.c., once daily for 14-16 weeks) reduces body weight in DIO mice.
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保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.268 ml	1.341 ml	2.682 ml
5 mM	0.054 ml	0.268 ml	0.536 ml
10 mM	0.027 ml	0.134 ml	0.268 ml
50 mM	0.005 ml	0.027 ml	0.054 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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