货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V46432-10μg	277.40 µM in Ethanol	￥2950.00 V46432-10μg ￥2950.00 3-5天	0 货期：3-5天	-	-	-	-
V46432-50μg	277.40 µM in Ethanol	￥7900.00 V46432-50μg ￥7900.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders.

体外研究：

Protectin D1 (1 μM, 24h) 通过上调 miRNA-210 表达和激活 PI3K/AKT 信号通路，在新生大鼠心肌细胞中发挥保护作用。

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.774 ml	13.87 ml	27.74 ml
5 mM	0.555 ml	2.774 ml	5.548 ml
10 mM	0.277 ml	1.387 ml	2.774 ml
50 mM	0.055 ml	0.277 ml	0.555 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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