货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V46456-1mg	11.38 mM in Methanol	￥1150.00 V46456-1mg ￥1150.00 3-5天	0 货期：3-5天	-	-	-	-
V46456-5mg	11.38 mM in Methanol	￥3500.00 V46456-5mg ￥3500.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.

体外研究：

GPP78 (Compound 8; 10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes.
GPP78 (Compound 8) inhibits the growth of most cell lines tested, with nanomolar potency (GI50) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic.

体内研究：

GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice.

参考文献：

1. Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53(2):616-23.
2. Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Ne웿Ů

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.275 ml	11.375 ml	22.751 ml
5 mM	0.455 ml	2.275 ml	4.55 ml
10 mM	0.228 ml	1.138 ml	2.275 ml
50 mM	0.046 ml	0.228 ml	0.455 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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