| 产品描述: | Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome. |
| 体外研究: |
Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM. Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively. |
| 保存条件: |
-20°C, 避光, 氮气保存 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.28 ml |
11.4 ml |
22.8 ml |
| 5 mM |
0.456 ml |
2.28 ml |
4.56 ml |
| 10 mM |
0.228 ml |
1.14 ml |
2.28 ml |
| 50 mM |
0.046 ml |
0.228 ml |
0.456 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |