| 产品描述: | Phenothiazine-d8 is the deuterium labeled Phenothiazine. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases. |
| 体外研究: |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. |
| 参考文献: |
1. Gao YQ, et al. Isolation and Characterization of Antifungal Metabolites from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. J Agric Food Chem. 2020 Feb 26;68(8):2418-2425. 2. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. 3. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35. 4. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31. |
| 保存条件: |
2-8°C, 避光, 氮气保存 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
4.823 ml |
24.117 ml |
48.235 ml |
| 5 mM |
0.965 ml |
4.823 ml |
9.647 ml |
| 10 mM |
0.482 ml |
2.412 ml |
4.823 ml |
| 50 mM |
0.096 ml |
0.482 ml |
0.965 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |