货号	规格	价格	上海	北京	珠海	重庆	武汉
V46578-1mg	≥98%	￥650.00 V46578-1mg ￥650.00 3-5天	0 货期：3-5天	-	-	-	-
V46578-5mg	≥98%	￥1600.00 V46578-5mg ￥1600.00 3-5天	0 货期：3-5天	-	-	-	-
V46578-10mg	≥98%	￥2600.00 V46578-10mg ￥2600.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

G12 (Ras 5-17) is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 can be used as a control of mutant Ras peptides studies (such V12).

体外研究：

DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM) and does not activate human M3 receptor (hM3). In addition to being inactive at hM3, DREADD agonist 21, a potent full agonist of hM3Dq (EC50=1.7 nM), is only 3.5-fold selective for hM3Dq over H1, 40-fold selective over 5HT2A, 100-fold selective over 5HT2C, and 165-fold selective over α1A. DREADD agonist 21 shows high binding affinities to 5HT2A and 5HT2C serotonin receptor, α1A adrenergic receptor, and H1 histamine receptor with Ki values of 66, 170, 280, and 6 nM, respectively.
DREADD agonist 21 potently activates hM1Dq, hM3Dq, and hM4Di. DREADD agonist 21 binds to hM1, hM4, hM1Dq and hM4Di receptors with pKis of 5.97, 5.44, 7.20, and 6.75, respectively. DREADD agonist 21 potently activates hM3Dq in Chinese hamster ovary (CHO) cells transfected cells in vitro with a pEC50 of 8.48±0.05. DREADD agonist 21 is a highly selective and potent agonist for muscarinic DREADDs (pEC50 for hM1Dq=6.54 and that for hM4Di=7.77 in pERK assays).

保存条件：

-20°C, 干燥, 避光, 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.854 ml	4.272 ml	8.544 ml
5 mM	0.171 ml	0.854 ml	1.709 ml
10 mM	0.085 ml	0.427 ml	0.854 ml
50 mM	0.017 ml	0.085 ml	0.171 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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