货号	规格	价格	上海	北京	珠海	重庆	武汉
V46630-1mg	≥98%	￥640.00 V46630-1mg ￥640.00 3-5天	0 货期：3-5天	-	-	-	-
V46630-5mg	≥98%	￥1690.00 V46630-5mg ￥1690.00 3-5天	0 货期：3-5天	-	-	-	-
V46630-10mg	≥98%	￥2790.00 V46630-10mg ￥2790.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

参考文献：

1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
2. Cherian OL, Menini A, Boccaccio A. Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13.
3. Piper AS, Greenwood IA. Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol. 2003 Jan138(1):31-8.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.324 ml	21.618 ml	43.236 ml
5 mM	0.865 ml	4.324 ml	8.647 ml
10 mM	0.432 ml	2.162 ml	4.324 ml
50 mM	0.086 ml	0.432 ml	0.865 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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