货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V46634-1mg	≥98%	￥4850.00 V46634-1mg ￥4850.00 3-5天	0 货期：3-5天	-	-	-	-
V46634-5mg	≥98%	￥10700.00 V46634-5mg ￥10700.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases.

体外研究：

SHP2 protein degrader-1 (compound SP4) (0-200 μM; 24 hours) inhibits the growth of Hela cells, with IC50 of 5.77 and 4.30 nM, respectively, which are about 100 times higher than the activity of SHP099 (SHP2 inhibitor).
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) induces 54.01% apoptotic death compared with 0.13% of the control at 100 nM.
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) induces cell cycle arrested at the G1 phase in Hela cells.
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) significantly inhibits the phosphorylation of JNK, Erk and p38.
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) inhibits RAS/MAPK signaling and cellular responses by a mechanism involving inhibition of SHP2 catalytic activity.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.1 ml	5.502 ml	11.003 ml
5 mM	0.22 ml	1.1 ml	2.201 ml
10 mM	0.11 ml	0.55 ml	1.1 ml
50 mM	0.022 ml	0.11 ml	0.22 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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