| 产品描述： | L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption. |
| 体外研究： |
L-873724 (Compound 22) is a potent and selective non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also shows IC50s of 95, 1221 and 4807 nM for Ramos cathepsin S, Hep G2 cathepsin L, Hep G2 cathepsin B. L-873724 exhibits an IC50 of 0.5 nM for rabbit cathepsin K. |
| 体内研究： |
L-873724 is orally bioavailable, non-lysosomotropic, and efficacious in the rhesus monkey bone resorption model. |
| 参考文献： |
1. Li CS, et al. Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1985-9.
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| 保存条件： |
2-8°C, 干燥, 避光 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.077 ml |
10.384 ml |
20.767 ml |
| 5 mM |
0.415 ml |
2.077 ml |
4.153 ml |
| 10 mM |
0.208 ml |
1.038 ml |
2.077 ml |
| 50 mM |
0.042 ml |
0.208 ml |
0.415 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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危险品化学品经营许可证（不带存储）
营业执照(三证合一)
