货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V46689-1mg	≥98%	￥2790.00 V46689-1mg ￥2790.00 3-5天	0 货期：3-5天	-	-	-	-
V46689-5mg	≥98%	￥7500.00 V46689-5mg ￥7500.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

LPA5 antagonist 1 (Compound 66) is a potent and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50=32 nM). LPA5 antagonist 1 shows high brain permeability and anti-nociceptive activity. LPA5 antagonist 1 can be used in inflammatory and neuropathic pain research. LPA5 antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究：

LPA5 antagonist 2 (0-10 μM) inhibits hLPA5 calcium mobilization with an IC50 value of 32 nM.
LPA5 antagonist 2 (0-10 μM) shows good target selectivity for LPA5.

体内研究：

LPA5 antagonist 1 (intraperitoneal injection; 17.8 mg/kg; once) treatment shows good brain exposure in vivo.
LPA5 antagonist 1 (intraperitoneal injection; 5.6, 10, and 17.8 mg/kg; once) treatment reduces mechanical allodynia in inflammatory pain model.

参考文献：

1. Zhang DH, et al. Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. Volume 243, 5 December

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.055 ml	10.276 ml	20.552 ml
5 mM	0.411 ml	2.055 ml	4.11 ml
10 mM	0.206 ml	1.028 ml	2.055 ml
50 mM	0.041 ml	0.206 ml	0.411 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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