货号	规格	价格	上海	北京	珠海	重庆	武汉
V46736-1mg	≥98%	￥2110.00 V46736-1mg ￥2110.00 3-5天	0 货期：3-5天	-	-	-	-
V46736-5mg	≥98%	￥4990.00 V46736-5mg ￥4990.00 3-5天	0 货期：3-5天	-	-	-	-
V46736-10mg	≥98%	￥7980.00 V46736-10mg ￥7980.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC50 of 18.1 nM and a Kd of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC50 s of 22 nM and 120 nM for electric eel and human AChE, respectively.

体外研究：

PCS1055 also antagonized functional signal transduction as demonstrates by the inhibition of agonist-stimulated GTP-γ-[35S] binding. PCS1055 inhibits G protein activation in a concentration dependent manner, with the highest potency at the M4 receptors. Both studies shows that PCS1055 is most potent at the M4 receptor subtype with a binding preference of 130-, 31.2-, 426- and >1000-fold, and functional preference of 255-, 69.1-, 342- and >1000-fold over the M1-, M2-, M3- and M5 receptors, respectively.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.06 ml	10.299 ml	20.598 ml
5 mM	0.412 ml	2.06 ml	4.12 ml
10 mM	0.206 ml	1.03 ml	2.06 ml
50 mM	0.041 ml	0.206 ml	0.412 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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