货号	规格	价格	上海	北京	珠海	重庆	武汉
V46742-1mg	≥98%	￥1350.00 V46742-1mg ￥1350.00 3-5天	0 货期：3-5天	-	-	-	-
V46742-5mg	≥98%	￥2990.00 V46742-5mg ￥2990.00 3-5天	0 货期：3-5天	-	-	-	-
V46742-10mg	≥98%	￥4790.00 V46742-10mg ￥4790.00 3-5天	0 货期：3-5天	-	-	-	-
V46742-25mg	≥98%	￥8630.00 V46742-25mg ￥8630.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD).

靶点：

JAK1:8.9 nM (IC50); JAK2:15 nM (IC50); JAK3:46.2 nM (IC50); NF-κB:150.7 nM (IC50); ISG:3.3 nM (IC50)

体外研究：

JAK-IN-23 inhibits JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively.
JAK-IN-23 shows potent inhibitory activities against ISG and NF-KB with IC50 values of 3.3 nM and 150.7 nM, respectively.
WB--- JAK-IN-23 (0.33μM, 1μM, 3μM; 24 h) can simultaneously block JAK-STAT1/3 and NF-κB proinflammatory signaling pathways in THP1-dual cells.
JAK-IN-23 (0.003-3 μM; 24 h) decreases the release of various proinflammatory factors, including IL-6, IL-8, IL-1β in THP1-dual cells stimulated by LPS.
JAK-IN-23 (0.11-3 μM; 24 h) decreases the release of various proinflammatory factors, including TNF-α, IL-12, IL-10 and IFNγ in LPS-induced peripheral blood mononuclear cells (PBMCs).
JAK-IN-23 (1 μM) inhibits the expression of a variety of inflammation-related genes induced by LPS, including IL-1B, TNF, IL12B, and IL-23A and has inhibitory effects on the expression of genes involved in the unfolded protein response that was induced by LPS (1 μg/mL).

体内研究：

JAK-IN-23 (1-5 mg/kg, oral) produces a strong anti-inflammatory activity in both dextran sulfate sodium (DSS) - and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute enteritis models and restores the structural composition of gut microbiota.

保存条件：

2-8°C, 干燥, 避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.266 ml	11.329 ml	22.658 ml
5 mM	0.453 ml	2.266 ml	4.532 ml
10 mM	0.227 ml	1.133 ml	2.266 ml
50 mM	0.045 ml	0.227 ml	0.453 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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