货号	规格	价格	上海	北京	珠海	重庆	武汉
V46851-1mg	≥98%	￥500.00 V46851-1mg ￥500.00 3-5天	0 货期：3-5天	-	-	-	-
V46851-5mg	≥98%	￥1000.00 V46851-5mg ￥1000.00 3-5天	0 货期：3-5天	-	-	-	-
V46851-10mg	≥98%	￥1500.00 V46851-10mg ￥1500.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

VSPPLTLGQLLS is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation.

体外研究：

VSPPLTLGQLLS (5 μM and 10 μM; 24 h and 48 h) inhibits human primary lymphatic endothelial cell (LEC)s proliferation, migration, and tubule formation.
VSPPLTLGQLLS shows effective inhibition in FGFR3 phosphorylation in LECs and also demonstrated to be effective in ATDC5 chondrogenic cells, 293T cells, explanted metatarsal bone cultures, and an in vivo mouse model of thanatophoric dysplasia II.
VSPPLTLGQLLS (10 μM; 6 h) inhibits tyrosine kinase activity of FGFR3 and its typical downstream molecules, extracellular signal-regulated kinase/mitogen-activated protein kinase.
VSPPLTLGQLLS (0, 1, 10, and 50 μM; 24 h and 3 or 7 days, respectively) also promotes proliferation and chondrogenic differentiation of cultured ATDC5 chondrogenic cells.
VSPPLTLGQLLS (10 μM; 0-60 min) inhibits the ERK/MAPK pathway in FGFR3-expressing chondrocytic cell line ATDC5.

保存条件：

-20°C,干燥, 避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.817 ml	4.083 ml	8.167 ml
5 mM	0.163 ml	0.817 ml	1.633 ml
10 mM	0.082 ml	0.408 ml	0.817 ml
50 mM	0.016 ml	0.082 ml	0.163 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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