货号	规格	价格	上海	北京	珠海	重庆	武汉
V46946-5mg	≥98%	￥1510.00 V46946-5mg ￥1510.00 3-5天	0 货期：3-5天	-	-	-	-
V46946-10mg	≥98%	￥2730.00 V46946-10mg ￥2730.00 3-5天	0 货期：3-5天	-	-	-	-
V46946-25mg	≥98%	￥5090.00 V46946-25mg ￥5090.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-2 increases detained intron splicing in cells.

体外研究：

OSMI-2 (Compound 1b; 20-50 μM; 4-24 hours; HCT116 cells) treatment reduces O-GlcNAc levels at short treatment times (<8h). However, O-GlcNAc levels begins to recover at longer treatment times with OSMI-2. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-2 (Compound 1b) is observed. Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-2 on cell growth in culture over 96h is also monitored. Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.
A time course performed with 20 μM OSMI-2 (Compound 1b) shows reciprocal changes in the abundance of OGT and OGA, with a particularly large increase in OGT; this may explain the recovery in O-GlcNAc levels with OSMI-2. At 24h where O-GlcNAc levels fully recovered.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.8 ml	8.999 ml	17.998 ml
5 mM	0.36 ml	1.8 ml	3.6 ml
10 mM	0.18 ml	0.9 ml	1.8 ml
50 mM	0.036 ml	0.18 ml	0.36 ml

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部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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