货号	规格	价格	上海	北京	珠海	重庆	武汉
V47015-1mg	≥98%	￥580.00 V47015-1mg ￥580.00 3-5天	0 货期：3-5天	-	-	-	-
V47015-5mg	≥98%	￥1290.00 V47015-5mg ￥1290.00 3-5天	0 货期：3-5天	-	-	-	-
V47015-10mg	≥98%	￥2090.00 V47015-10mg ￥2090.00 3-5天	0 货期：3-5天	-	-	-	-
V47015-25mg	≥98%	￥4390.00 V47015-25mg ￥4390.00 3-5天	0 货期：3-5天	-	-	-	-
V47015-50mg	≥98%	￥7030.00 V47015-50mg ￥7030.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo.

体内研究：

SHP2-IN-9 (compound 2) could effectively inhibit SHP2-mediated cell signaling pathways in cancer (cervix cancer, human pancreatic cancer, large cell lung cancer and mouse glioma cell) by inhibiting the phosphorylation of Paxillin, affecting the regulation of the PI3K/AKT pathway and cell proliferation by causing the cell cycle arrest and inducing the early apoptosis.

参考文献：

1. Ma Y, et al. Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database. Bioorg Chem. 2022;121:105648.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.594 ml	12.972 ml	25.943 ml
5 mM	0.519 ml	2.594 ml	5.189 ml
10 mM	0.259 ml	1.297 ml	2.594 ml
50 mM	0.052 ml	0.259 ml	0.519 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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