货号	规格	价格	上海	北京	珠海	重庆	武汉
V47019-5mg	≥98%	￥990.00 V47019-5mg ￥990.00 3-5天	0 货期：3-5天	-	-	-	-
V47019-10mg	≥98%	￥1590.00 V47019-10mg ￥1590.00 3-5天	0 货期：3-5天	-	-	-	-
V47019-25mg	≥98%	￥3490.00 V47019-25mg ￥3490.00 3-5天	0 货期：3-5天	-	-	-	-
V47019-50mg	≥98%	￥5490.00 V47019-50mg ￥5490.00 3-5天	0 货期：3-5天	-	-	-	-
V47019-100mg	≥98%	￥8770.00 V47019-100mg ￥8770.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC50s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis.

靶点：

hCB1-R:56.15 nM (EC50); cannabinoid type-2 receptors:11.63 nM (EC50)

体外研究：

CB1/2 agonist 1 (5-50 mg/kg) dose-dependently relieves neuropathic pain in a mouse model of oxaliplatin-induced neuropathic pain.

体内研究：

CB1/2 agonist 1 (compound B2) (10 µM) inhibits AEA hydrolysis with an IC50 of 5.9 µM for FAAH.
CB1/2 agonist 1 shows high affinity for CB1R and CB2R with Kis of 2.9, 1.5 nM, respectively.
CB1/2 agonist 1 (10 µM) shows anti-inflammatory effect and significantly decreases the secretion of IL-1β and IL-6, increases the release of anti-inflammatory IL-10 to 483.7% in LPS-activated BV-2 cells.
CB1/2 agonist 1 (1, 10 µM) inhibits 4-AP-evoked glutamate release.

参考文献：

1. Arena C, et al. The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. Eur J Med Chem. 2020 Dec 15;208:112858.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.297 ml	11.486 ml	22.971 ml
5 mM	0.459 ml	2.297 ml	4.594 ml
10 mM	0.23 ml	1.149 ml	2.297 ml
50 mM	0.046 ml	0.23 ml	0.459 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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