货号	规格	价格	上海	北京	珠海	重庆	武汉
V47076-1mg	≥98%	￥850.00 V47076-1mg ￥850.00 3-5天	0 货期：3-5天	-	-	-	-
V47076-5mg	≥98%	￥2440.00 V47076-5mg ￥2440.00 3-5天	0 货期：3-5天	-	-	-	-
V47076-10mg	≥98%	￥3910.00 V47076-10mg ￥3910.00 3-5天	0 货期：3-5天	-	-	-	-
V47076-25mg	≥98%	￥7040.00 V47076-25mg ￥7040.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects.

体外研究：

MS67 (0.001-1 μM) induces WDR5 degradation at a concentration as low as 1 nM. MS67 induces WDR5 depletion much more effectively in all six mixed lineage leukemia (MLL)-r acute myeloid leukemia (AML) and four pancreatic ductal adenocarcinoma (PDAC) cell lines without a hook effect and in a concentration-dependent manner in PDAC cells.
MS67 decreases H3K4me2/3 in both MV4;11 and MIA PaCa-2 cells, whereas other examined histone methylation marks such as H3K9me3, H3K27me3, and H3K36me3 are not affected . MS67 is effective in suppressing both WDR5-related gene expression programs and WDR5/MLL-induced H3K4 methylations on chromatin.
The GI50 values of MS67 in the two most sensitive AML lines, MV4;11 and EOL-1, are 15 nM and 38 nM, respectively. MLL-r acute leukemia cell lines including MV4;11, EOL-1, MOLM13, KOPN8, RS4;11, and THP-1 are sensitive to MS67, whereas leukemia cell lines that did not harbor MLL-r (including K562, HL60, and a murine AML line transformed by Hoxa9 plus Meis1) are insensitive to MS67.
. MS67 binds to VCB (VHL-Elongin C-Elongin B ternary complex), with a Kd of 140 nM.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.971 ml	4.854 ml	9.707 ml
5 mM	0.194 ml	0.971 ml	1.941 ml
10 mM	0.097 ml	0.485 ml	0.971 ml
50 mM	0.019 ml	0.097 ml	0.194 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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