货号	规格	价格	上海	北京	珠海	重庆	武汉
V47099-1mg	≥98%	￥2030.00 V47099-1mg ￥2030.00 3-5天	0 货期：3-5天	-	-	-	-
V47099-5mg	≥98%	￥4490.00 V47099-5mg ￥4490.00 3-5天	0 货期：3-5天	-	-	-	-
V47099-10mg	≥98%	￥7180.00 V47099-10mg ￥7180.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research.

体外研究：

Glucosylceramide synthase-IN-2 (compound T-690; po; 30, 100, 300 mg/kg) reduces GlcCer concentrations in the plasma and cerebral cortex in a dose-dependent manner in C57BL/6J mice[1].
Glucosylceramide synthase-IN-2 (po; 5 mg/kg) has a Cmax of 416 ng/mL. Glucosylceramide synthase-IN-2 shows good oral exposure (BA = 31%)[1].
Glucosylceramide synthase-IN-2 reveals good brain exposure (Cu,brain = 0.21 μM at 30 mg/kg dosing, 1 h)[1].

体内研究：

Glucosylceramide synthase-IN-2 (compound T-690) has no SERT inhibitory activity (IC50>10 μM). Glucosylceramide synthase-IN-2 does not affect GCase activity (EC50>300 μM).
Glucosylceramide synthase-IN-2 (30 μM) does not potently inhibit hERG, CaV1.2, and NaV1.5 channels.

保存条件：

2-8°C, 避光, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.235 ml	11.175 ml	22.351 ml
5 mM	0.447 ml	2.235 ml	4.47 ml
10 mM	0.224 ml	1.118 ml	2.235 ml
50 mM	0.045 ml	0.224 ml	0.447 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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