| 产品描述: | Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system. Avacincaptad pegol sodium treats Geographic atrophy (GA) mice. |
| 参考文献: |
1. Joshua Ong, et al. The Complement System as a Therapeutic Target in Retinal Disease. Medicina (Kaunas). 2024 Jun 5;60(6):945. 2. Yiming Li, et al. Targeting both C5 and HTRA1 provides additional rescue effect in NaIO3-induce GA model. IOVS. June 202 웿 Ů ñ 샮㡽䇘睜⪰ޏࠃ 䇩睜 䇩睜Ȃ Ӥ 晐睦Ӥ 晐睦Ӥ 峀睜 弴睜 ڤ 犐ƈ ڤ郥댻嬧睜Ӥ 乨Ƥ鄩댻婯睜Љ �ޝ乜Ƥ媜睜 Ӥ ItemҮ쎾番莰ଁ뢜సങ獲䥷唍⋠హ ⾈హ�唒హ ଁ 敖ﰨ 唎֞ ﰰ 䨬{�唒హ 쉢W⾈హ 稼Č 滛ﰰ靖 슸Wﰜ싛W幌Čﰰ䨬{ 싚W싢W幌Čﱈ䨔{犐ƈ >†靅댻EOF F Item Count 婯睜Љ ɾ쎾番荘ଁ랜సi ﰜﶴﱌ 랜సﱬ먙唌랜స荘ଁi ﰜﶴﱌ먰唌荘ଁ 翨Ƅ 杹畦茀ଁ莰ଁ翨 |
| 保存条件: |
-20°C, 干燥 |
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| 注意: |
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