货号	规格	价格	上海	北京	珠海	重庆	武汉
V47326-1mg	≥98%	￥2190.00 V47326-1mg ￥2190.00 3-5天	0 货期：3-5天	-	-	-	-
V47326-5mg	≥98%	￥5390.00 V47326-5mg ￥5390.00 3-5天	0 货期：3-5天	-	-	-	-
V47326-10mg	≥98%	￥8630.00 V47326-10mg ￥8630.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells.

体外研究：

S2157 (50 mg/kg; IP; 3 times a week; for 28 days) causes the size of subcutaneous tumors reduced to less than 20% of that in the untreated control[1].
S2157 (50 mg/kg; IP) has a T1/2 of 0.88 hours, a Cmax of 4.33 μM and an AUC of 5.75 μM•h[1].
S2157 (30 mg/kg or 50 mg/kg; twice a week for 3 weeks) almost completely suppressed the growth of MOLT4 cells in most but not all NOD/SCID mice with MOLT4 cells. S2157 eradicates CNS leukemia in murine xenotransplanted models[1].

体内研究：

S2157 is particularly effective for T-ALL cell lines with the IC50 values between 1.1 µM for human T-ALL cell lines CEM and 6.8 µM for MOLT4.
S2157 (4-20 µM; 72 hours) modestly inhibits mitogen-activated normal T-lymphocytes.
S2157 (4-8 µM; 24 hours) induces apoptosis and down-regulates the expression of NOTCH3 and TAL1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) cells.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.213 ml	11.063 ml	22.127 ml
5 mM	0.443 ml	2.213 ml	4.425 ml
10 mM	0.221 ml	1.106 ml	2.213 ml
50 mM	0.044 ml	0.221 ml	0.443 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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