货号	规格	价格	上海	北京	珠海	重庆	武汉
V47426-1mg	≥98%	￥1590.00 V47426-1mg ￥1590.00 3-5天	0 货期：3-5天	-	-	-	-
V47426-5mg	≥98%	￥4190.00 V47426-5mg ￥4190.00 3-5天	0 货期：3-5天	-	-	-	-
V47426-10mg	≥98%	￥6700.00 V47426-10mg ￥6700.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitt’s lymphoma. JS25 effectively crosses the blood-brain barrier.

体外研究：

JS25 (10 mg/kg and 20 mg/kg; i.p.; every 2 days, for 14 d) inhibits tumor growth and results a significant reduction in their secondary tumor formation in murine xenograft model of Burkitt’s lymphoma[1].
JS25 (1, 2.5, and 5 μM; injection; every day for 2 days) decreases tumor burden in zebrafish patient-derived xenografts of chronic lymphocytic leukemia, wich efficacy is better than Ibrutinib.html" class="link-product" target="_blank">Ibrutinib [1].

体内研究：

JS25 (0-50 μM; 72 h) inhibits the proliferation of myeloid and lymphoid B-cell cancer cell lines. JS25 shows inhibitory capability against BTK, BMX, ITK, TXK, TEC, and BLK with IC50s of 28.5 nM, 49.0 nM, 0.44 μM, 0.19 μM, 0.22 μM, and 2.60 μM, respectively; shows little inhibition against other BTK pathway-related proteins (EGFR, ERBB2, and JAK3), with IC50>3 μM. JS25 presents a more favorable selectivity profile than Ibrutinib.html" class="link-product" target="_blank">Ibrutinib and Acalabrutinib.html" class="link-product" target="_blank">Acalabrutinib .
JS25 (10 μM; 0, 4, 15 h) degrades BTK and inhibits both the catalytic activity and the expression of BTK in tumor cells.
JS25 (10 μM; 72 h) inhibits the tumor growth of Burkitt’s lymphoma and induces selective ex vivo cytotoxicity in primary diffuse large B-cell lymphoma (DLBCL) samples.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.906 ml	9.531 ml	19.063 ml
5 mM	0.381 ml	1.906 ml	3.813 ml
10 mM	0.191 ml	0.953 ml	1.906 ml
50 mM	0.038 ml	0.191 ml	0.381 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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