货号	规格	价格	上海	北京	珠海	重庆	武汉
V47534-5mg	≥98%	￥1140.00 V47534-5mg ￥1140.00 3-5天	0 货期：3-5天	-	-	-	-
V47534-10mg	≥98%	￥1870.00 V47534-10mg ￥1870.00 3-5天	0 货期：3-5天	-	-	-	-
V47534-25mg	≥98%	￥3740.00 V47534-25mg ￥3740.00 3-5天	0 货期：3-5天	-	-	-	-
V47534-50mg	≥98%	￥5980.00 V47534-50mg ￥5980.00 3-5天	0 货期：3-5天	-	-	-	-
V47534-100mg	≥98%	￥9570.00 V47534-100mg ￥9570.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Dalmelitinib is an orally active selective c-Met kinase inhibitor (IC50: 2.9 nM) that binds to the ATP-binding region of c-Met. Dalmelitinib induces the phosphorylation of MET, partially or completely inhibits the phosphorylation of AKT and ERK. Dalmelitinib potently inhibits cancer cell (c-Met oncogene amplification) proliferation, and is used for the research of cancers like human non-small cell lung cancer (NSCLC).

体外研究：

Dalmelitinib (Compound 4 d, intragastric administration, 10-60 mg/kg) significantly inhibits the tumor growth in a dose-dependent manner in MKN-45 tumor xenograft nude mice.
Dalmelitinib (intragastric administration, 5 mg/kg for a single dose) shows a high plasma concentration, longer half-life and mean residence time, low clearance rates in BALB/c small nude mice.
Dalmelitinib shows a high level of No Observed Adverse Effect Level (NOAEL) in mice long-term toxicity (225 mg/kg/day) and acute toxicity (600 mg/kg/day).

体内研究：

Dalmelitinib (Compound 4 d) binds to the ATP-binding region of c-Met kinase, and shows slective inhibitory activity against c-Met with an IC50 value of 2.9 nM.
Dalmelitinib (0-1 μM approximately, 3 days) inhibits cell proliferation in various c-Met oncogene amplification cancer cell lines, with IC50 values ranging from 6 nM to 33 nM.
Dalmelitinib (0.1-1 μM, 6-24 h) significantly induces the phosphorylation of the tyrosine kinases (MET), partially or completely inhibits the downstream phosphorylation of ERK and AKT in HCCLM3 cells.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.167 ml	10.835 ml	21.67 ml
5 mM	0.433 ml	2.167 ml	4.334 ml
10 mM	0.217 ml	1.083 ml	2.167 ml
50 mM	0.043 ml	0.217 ml	0.433 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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