货号	规格	价格	上海	北京	珠海	重庆	武汉
V47557-5mg	≥98%	￥930.00 V47557-5mg ￥930.00 3-5天	0 货期：3-5天	-	-	-	-
V47557-10mg	≥98%	￥1560.00 V47557-10mg ￥1560.00 3-5天	0 货期：3-5天	-	-	-	-
V47557-25mg	≥98%	￥3140.00 V47557-25mg ￥3140.00 3-5天	0 货期：3-5天	-	-	-	-
V47557-50mg	≥98%	￥5030.00 V47557-50mg ￥5030.00 3-5天	0 货期：3-5天	-	-	-	-
V47557-100mg	≥98%	￥8040.00 V47557-100mg ￥8040.00 3-5天	0 货期：3-5天	-	-	-	-

大包装询价收藏产品

加入购物车

到货通知，提交手机号入库后将短信通知。

产品描述：

NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC50 of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier.

体外研究：

NAB-14 (20 mg/kg; p.o.) shows high systemic exposure with peak brain free of 3.2 and 3.8 nM for mouse and rat, respectively.

体内研究：

NAB-14 (compound 14) shows inhibition with IC50s of 15 µM and 5.1 µM for GluN1/2AC1/2CC2 and GluN1/2AC1/2CC2 receptors, respectively.
NAB-14 (20 µM; 24 h) inhibits native GluN2D-containing receptors in brain slices with no effect on native GluN2A- or GluN2B-containing NMDARs in cultures cortical neurons.
NAB-14 (10 µM) reduces the peak amplitude of evoked EPSCs to 55 ± 3.0%, and significantly reduced the τW of EPSC deactivation.
NAB-14 (10 µM) decreases the peak amplitude and charge transfer of interneuron EPSCs to 59 ± 9.9% and 63 ± 9.7%, respectively. And NAB-14 decreases τW for interneuron EPSCs from 150 ± 12 ms to 101 ± 14 ms.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.846 ml	14.229 ml	28.458 ml
5 mM	0.569 ml	2.846 ml	5.692 ml
10 mM	0.285 ml	1.423 ml	2.846 ml
50 mM	0.057 ml	0.285 ml	0.569 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置