货号	规格	价格	上海	北京	珠海	重庆	武汉
V47627-1mg	≥98%	￥480.00 V47627-1mg ￥480.00 3-5天	0 货期：3-5天	-	-	-	-
V47627-5mg	≥98%	￥997.00 V47627-5mg ￥997.00 3-5天	0 货期：3-5天	-	-	-	-
V47627-10mg	≥98%	￥1620.00 V47627-10mg ￥1620.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection.

体外研究：

Larazotide (1-100 μM; 5 d) affects Vero cell growth.
Larazotide (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively.
Larazotide (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells.
Larazotide (100 μM; 3 h) inhibits gliadin translocation across Caco-2 monolayers.
Larazotide (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells.

参考文献：

1. Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427.
2. Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.378 ml	6.889 ml	13.777 ml
5 mM	0.276 ml	1.378 ml	2.755 ml
10 mM	0.138 ml	0.689 ml	1.378 ml
50 mM	0.028 ml	0.138 ml	0.276 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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