货号	规格	价格	上海	北京	珠海	重庆	武汉
V47669-1mg	≥98%	￥650.00 V47669-1mg ￥650.00 3-5天	0 货期：3-5天	-	-	-	-
V47669-5mg	≥98%	￥1600.00 V47669-5mg ￥1600.00 3-5天	0 货期：3-5天	-	-	-	-
V47669-10mg	≥98%	￥2600.00 V47669-10mg ￥2600.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.

体外研究：

LAH4 is capable of complexing DNA, associating with the cell surfacemembrane and then, when enveloped within an endosome, disrupts the endosomal membrane as the pH drops.
LAH4 possesses robust plasmid DNA transfection properties. Peptides of the LAH4 family are able to efficiently deliver siRNAs in vitro into a human cell line.
LAH4 is found to mediate the intracellular delivery of both protein and nucleotide cargo and facilitate protein internalization using mechanisms involving endosomal acidification and processing through the proteasome pathway, leading to enhanced cross presentation of protein antigen by dendritic cells to CD8+ T cells. LAH4 also improves the internalization of CpG, resulting in NF-kB activation, thus potentiating the adjuvant effect of CpG.
LAH4 exhibits antibiotic activities against Escherichia coli and Bacillus subtilis. the peptide does not, however, lyse human red blood cells at bacteriocidal concentrations. The antibiotic activities of LAH4 are 2 orders of magnitude more pronounced at pH 5 when compared with pH 7.5.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.36 ml	1.799 ml	3.598 ml
5 mM	0.072 ml	0.36 ml	0.72 ml
10 mM	0.036 ml	0.18 ml	0.36 ml
50 mM	0.007 ml	0.036 ml	0.072 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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