| 产品描述: | D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50 = 24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2 . D18 has strong immune activation and anti-tumor activity. D18 commonly used in cancer research, such as colon cancer. |
| 体外研究: |
D18 (0.1-0.5 μg/mL,12 小时) 显著诱导 hPBMCs 中 IFN-γ、TNF-α、IL-1β、IL-12 p40 和 IP-10 浓度的增加。 |
| 保存条件: |
-20°C |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.744 ml |
13.718 ml |
27.436 ml |
| 5 mM |
0.549 ml |
2.744 ml |
5.487 ml |
| 10 mM |
0.274 ml |
1.372 ml |
2.744 ml |
| 50 mM |
0.055 ml |
0.274 ml |
0.549 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |